Bodipy-based photosensitizers with long alkyl tails at the meso position: efficient singlet oxygen generation in Cremophor-EL micelles

Kilic B., Yesilgul N., Polat V., Gercek Z., Akkaya E. U.

Tetrahedron Letters, vol.57, no.12, pp.1317-1320, 2016 (SCI-Expanded, Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 57 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.1016/j.tetlet.2016.02.033
  • Journal Name: Tetrahedron Letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1317-1320
  • Keywords: Bodipy, Organic chromophores, Organic photochemistry, Photosensitizers, Singlet oxygen
  • Police Academy Affiliated: No

Abstract

Bodipy dyes with n-decyloxyphenyl-(4, 5) and pentadecyl-(8) meso substituents can easily embed themselves into micellar structures formed from Cremophor-EL. In micelles of approximately 20 nm median size, heavy-atom substituted dyes show remarkable photosensitization properties as evidenced by the rate of reaction with an anthracene-based selective singlet oxygen trap in buffered aqueous solutions. Considering the ease of Bodipy derivatization and the advantages of Cremophor-EL carried therapeutic agents, these photosensitizing agents may offer novel targeting opportunities and enhanced chemical and photophysical stability.