Singlet Oxygen Generation with Chemical Excitation of an Erythrosine-Luminol Conjugate
ACS Omega, cilt.2, sa.4, ss.1367-1371, 2017 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.1021/acsomega.7b00228
- Dergi Adı: ACS Omega
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1367-1371
- Polis Akademisi Adresli: Hayır
Özet
Chemical generation of singlet oxygen under biologically relevant conditions is very important, considering the role played by singlet oxygen in cancer therapeutics. We now demonstrate that a luminol derivative can be chemically excited and transfer the excitation energy to the covalently attached photosensitizer derived from erythrosin. A photosensitizer module, when excited in this manner, can generate singlet oxygen in solution. As hydrogen peroxide is present in a relatively high concentration in cancer cells, singlet oxygen generation through chemical excitation may evolve into an important therapeutic approach.