Singlet Oxygen Generation with Chemical Excitation of an Erythrosine-Luminol Conjugate
ACS Omega, vol.2, no.4, pp.1367-1371, 2017 (Scopus)
- Publication Type: Article / Article
- Volume: 2 Issue: 4
- Publication Date: 2017
- Doi Number: 10.1021/acsomega.7b00228
- Journal Name: ACS Omega
- Journal Indexes: Scopus
- Page Numbers: pp.1367-1371
- Police Academy Affiliated: No
Abstract
Chemical generation of singlet oxygen under biologically relevant conditions is very important, considering the role played by singlet oxygen in cancer therapeutics. We now demonstrate that a luminol derivative can be chemically excited and transfer the excitation energy to the covalently attached photosensitizer derived from erythrosin. A photosensitizer module, when excited in this manner, can generate singlet oxygen in solution. As hydrogen peroxide is present in a relatively high concentration in cancer cells, singlet oxygen generation through chemical excitation may evolve into an important therapeutic approach.