Proof-of-principle for two-stage photodynamic therapy: Hypoxia triggered release of singlet oxygen

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Ayan S., GÜNAYDIN G., Yesilgul-Mehmetcik N., Gedik M. E., Seven O., Akkaya E. U.

Chemical Communications, vol.56, no.94, pp.14793-14796, 2020 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 94
  • Publication Date: 2020
  • Doi Number: 10.1039/d0cc06031c
  • Journal Name: Chemical Communications
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Communication Abstracts, EMBASE, MEDLINE, DIALNET
  • Page Numbers: pp.14793-14796
  • Open Archive Collection: AVESIS Open Access Collection
  • Police Academy Affiliated: No

Abstract

We propose to overcome oxygen deficiency and light attenuation problems in photodynamic therapy (PDT), by separating photoexcitation and singlet oxygen delivery of the PDT process into two distinct operations to be carried out sequentially, at different locations. We now demonstrate the viability of this approach, using 2-pyridone derivative which yields a relatively stable endoperoxide. The initial storage endoperoxide obtained is transformed enzymatically into a more labile compound when placed in hypoxic cell cultures, and releases singlet oxygen significantly faster. The potential of this approach in advancing PDT beyond its current limits is exciting. This journal is