Proof-of-principle for two-stage photodynamic therapy: Hypoxia triggered release of singlet oxygen

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Ayan S., GÜNAYDIN G., Yesilgul-Mehmetcik N., Gedik M. E., Seven O., Akkaya E. U.

Chemical Communications, cilt.56, sa.94, ss.14793-14796, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 94
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1039/d0cc06031c
  • Dergi Adı: Chemical Communications
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Communication Abstracts, EMBASE, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.14793-14796
  • Polis Akademisi Adresli: Hayır

Özet

We propose to overcome oxygen deficiency and light attenuation problems in photodynamic therapy (PDT), by separating photoexcitation and singlet oxygen delivery of the PDT process into two distinct operations to be carried out sequentially, at different locations. We now demonstrate the viability of this approach, using 2-pyridone derivative which yields a relatively stable endoperoxide. The initial storage endoperoxide obtained is transformed enzymatically into a more labile compound when placed in hypoxic cell cultures, and releases singlet oxygen significantly faster. The potential of this approach in advancing PDT beyond its current limits is exciting. This journal is